Native American Business Development Enhancement Act of 2009

Native American Business Development Enhancement Act of 2009 - Amends the Small Business Act to establish in the Small Business Administration (SBA) the Office of Native American Affairs, administered by a new SBA Associate Administrator, to increase Native American entrepreneurship. Authorizes appropriations.

Authorizes the SBA's Administrator (acting through the Associate Administrator) to: (1) operate a Tribal Business Information Centers program that provides Native American populations with business training and entrepreneurial development assistance; (2) designate entities as Centers; (3) contribute agency personnel and resources to the centers; and (4) make grants to the centers. Authorizes appropriations.

Allows any eligible Center to apply for an additional grant to assist with outreach, development, and enhancement on Indian lands of small business startups and expansions owned by Indian tribe members, Alaska Natives, and Native Hawaiians. Requires, to be eligible, that the Center be in a state in which the combined Indian Tribe members, Alaska Natives, and Native Hawaiians make up at least one percent of the state's total population. Authorizes appropriations.