| Shyster | O | PA |
| Shyyan Scott Brooks | P | OH |
| Siadek for Senate | S | NE |
| Sia for Congress | H | MD |
| Sia Lo for Congress | H | MN |
| Sick of D.C. for Congress | H | AL |
| Sidecar Health INC. Political Action Committee | N | CA |
| Side Door PAC | O | TX |
| Sid for Congresss | H | IN |
| Sid for Office | H | NC |
| Sidley Austin LLP Good Government Fund | Q | IL |
| Siebe 2020 for Ord1 | H | OR |
| Siedenbuehl for Congress | H | PA |
| Siembra PAC | V | NC |
| Siemens Corporation PAC | Q | DC |
| Siemens Energy, INC. PAC | Q | DC |
| Siena Progressive Coalition | N | NV |
| Sierra Club | I | CA |
| Sierra Club | C | CA |
| Sierra Club Independent Action | O | CA |
| Sierra Club Political Committee | Q | CA |
| Sierra County Democratic Central Committee | X | CA |
| Sierra Forward | V | CA |
| Sierra Nevada Corporation PAC | Q | NV |
| Sierra Space Corporation PAC | N | CO |
| Sifton for US Senate | S | MO |
| Sigler for Senate | S | LA |
| Sigmapac1914 | V | DC |
| Signorello for Senate | S | NJ |
| Signs4politics | N | NV |
| Signs of Texas Liberty PAC | N | TX |
| SIG Sauer, INC. Political Action Committee (Aka 'Sig Sauer Pac') | N | NH |
| Sikh Impact | N | NJ |
| Sikh PAC | Q | CA |
| Silencer Central PAC | N | CA |
| Silent Majority Network | O | CT |
| Silent No More | O | PA |
| Silicon Slopes PAC | O | UT |
| Silicon Valley Bank PAC | Q | CA |
| Silicon Valley Democratic Club | Q | CA |
| Silk for Congress | H | OK |
| Silk PAC | Q | NJ |
| Silky for Congress | H | TX |
| Silva for Congress | H | CA |
| Silver Lining Victory Fund | S | DC |
| Silver Spring Progressive Action | N | MD |
| Silver Sprout Aid Alliance | O | TX |
| Silver State PAC, INC. | O | FL |
| Silver State Victory 2022 | N | AZ |
| Sima for Texas | H | TX |
| Sima Victory Fund | N | TX |
| Simi Valley Democratic Club | X | CA |
| Simmes 4 Vice President | P | CA |
| Simmons First National Bank Political Action Committee (Simpac) Federal Fund | Q | AR |
| Simon Alvarez As Your Congressman | H | CA |
| Simon Alvarez for Congress | H | CA |
| Simon for Congress | H | CA |
| Simonforcongress | H | NV |
| Simon Group Holdings 1 LLC PAC | N | MI |
| Simon Winston for Congress | H | TX |
| Simple Idea Super PAC | O | FL |
| Simple PAC | N | NC |
| Simpson for America | H | NC |
| Simpson for Congress | H | ID |
| Simpson for Congress Committee | H | IA |
| Sims4pres.Net Candidate Gregory Evans Sims | P | TX |
| Sims for Nevada, INC. | H | NV |
| Sinclair Broadcast Group PAC | Q | MD |
| Sindhi American Political Action Committee | N | DC |
| Sindhi American Political Action Committee | N | CT |
| Sinema for Arizona | S | AZ |
| Sinema Kennedy Victory Fund | H | DC |
| Sinema Leadership Fund | N | AZ |
| Singer for Congress | H | NV |
| Singer for Senate | S | UT |
| Singh for Senate | S | NJ |
| Singh for Senate | S | NJ |
| Singh PAC | Q | MI |
| Single Payer Action Now (Spon) | N | FL |
| Single Payer Option Now (Spon) | N | FL |
| Single Subject Amendment | N | FL |
| Singletary 4 Congress | H | NY |
| Siouxland Energy & Livestock Cooperative PAC | N | IA |
| Siouxland Ethanol LLC PAC | N | NE |
| Sipes for Congress | H | OK |
| Sires for Congress | H | NJ |
| Sirius Xm Radio INC. and Pandora Media, LLC PAC (Siriusxm Pandora Pac) | Q | NY |
| Siskiyou County Republican Central Committee (Federal) | X | CA |
| Sister District Project | N | CA |
| Sisterhood 2024 | I | NC |
| Sisters Saving Lives | N | DC |
| Sites for Congress | H | OH |
| Sittner for US | H | UT |
| Sitv INC PAC | N | CA |
| Sivalingam for Senate | S | NH |
| Six for President 2020 | X | CA |
| Six Political Action Committee | N | WI |
| Sixteen Thirty Fund/Make It Work Action | I | DC |
| Sixteen Thirty Fund/Not One Penny | I | DC |
| Sixth District Democratic Party of Wisconsin | Y | WI |
| Sixty Million Cracks | O | MI |
| Siyaa African Political Action Committee | N | NY |
| Skadden Arps Political Action Committee | Q | DC |
| Skarlatos for Or-04 | H | MD |
| Skarlatos for Or-04 2022 | H | MD |
| Skinner for America | H | FL |
| Skipac | Q | MD |
| Skip Sandman Campaign Committee | H | MN |
| Skssusan | U | IN |
| Sky Committee | P | AZ |
| Sky Is Blue | O | DC |
| Skylar for Congress | H | PA |
| Skylarforuscongress | H | MT |
| Slatenc (Sparking Local Action Through Engagment Nc) | N | NC |
| Slauson for Congress | H | CA |
| Slavic Peoples Initiative | N | IL |
| Slemmons for Oklahoma | H | OK |
| Slm Corporation PAC (Sallie Mae Pac) | Q | DE |
| Slo County Democratic Party-Federal | Y | CA |
| Slocum for Congress | H | MI |
| Slotkin Crow Spanberger Victory Fund | N | DC |
| Slotkin Hertel Victory Fund | S | DC |
| Slotkin Schiff Alsobrooks Victory Fund | S | DC |
| Slotkin Spanberger Victory Fund | H | DC |
| Slotkin Stevens Victory | H | DC |
| Slotkin Victory Fund | N | DC |
| Slotkin Victory Fund | N | MI |
| Slotta for North Carolina | H | NC |
| Sls Victory Committee | H | MD |
| Smallbizadvocates.Org | O | AZ |
| Smallbizpros INC-Padgett Business Services PAC (Or) Sbp INC-Padgett Business Services PAC | Q | GA |
| Small Business Advocates | O | OH |
| Small Business Council of America-PAC, INC. | Q | GA |
| Small Business Finance Association PAC | N | NY |
| Small Business Investor Alliance PAC | Q | DC |
| Small Business Richmond PAC | N | VA |
| Small D Action PAC | O | NM |
| Small Maufacturers of America PAC | N | DC |
| Smart for Congress | H | SC |
| Smart Justice America Action Fund | O | CA |
| Smart Political Action League Local 137 | N | NY |
| Smart Solutions PAC | Q | DC |
| Smart Td PAC | Q | OH |
| Smash Socialism Now | O | VA |
| Smiledirectclub, INC. PAC (Smile Pac) | N | TN |
| Smiley for Congress | H | VA |
| Smiley for Wa Senate Republican Nominee Fund 2022 | S | VA |
| Smiley for Washington INC. | S | VA |
| Smiley Victory Fund | N | VA |
| Smi-PAC of Kentucky | Q | KY |
| Smithfield Foods INC Political Action Committee (Hampac) | Q | VA |
| Smith for Congress | H | IN |
| Smith for President 2032 | P | TN |
| Smith for the Future | X | NC |
| Smith for the People | P | IL |
| Smith for US Senate | S | TN |
| Smith Gambrell and Russell Political Action Committee Trust | Q | GA |
| Smith & Nephew, INC. PAC (S+N Pac) | Q | DC |
| Smiths Group Services Corporation Political Action Committee | Q | DC |
| Smith U S Senate Committee | S | MO |
| Smith Victory | N | GA |
| Smith & Wesson Brands, INC. Political Action Committee | N | MA |
| Smitty for Congress | H | TX |
| Smoak 2020 | H | WA |
| Smoke Bend Associates LLC Federal Political Action Committee | Q | LA |
| Smp | O | DC |
| Smucker for Congress | H | GA |
| Smucker Victory Committee | N | GA |
| Snack Food Association Political Action Committee (Snackpac) | Q | VA |
| Snake River Citizens for Liberty PAC, INC. | O | ID |
| Snake River Salmon Society | N | ID |
| Snake River Sugar Company Political Action Committee | Q | ID |
| Snoco Citizens for New Leadership | N | WA |
| Snohomish County Democratic Socialists of America | I | WA |
| Snooks Bouska for President | P | IA |
| Snow PAC | H | OH |
| Snowpac Utah (Snowpac) | N | UT |
| Soares 2024 | P | MA |
| Soave for Congress | H | KS |
| Socal Health Care Coalition A Project of Sixteen Thirty Fund | E | DC |
| Socal Health Care Coalition A Project of Sixteen Thirty Fund | I | DC |
| So Cal Victory Fund | H | CA |
| Soccer Voter Super PAC | O | NY |
| Socialist National Committee | Y | NY |
| Socialist PAC | O | MD |
| Socialist Workers National Campaign Committee | X | NY |
| Social Justice Labor Movement | S | FL |
| Socially Responsible Government | N | MI |
| Social Media Ecosystem Political Action Committee | U | DC |
| Social Progress in Union With Economic Growth | O | NJ |
| Social Security Party | X | CT |
| Social Security Reform Now | N | VA |
| Social Security Works PAC | Q | DC |
| Societas Signum Draconis | X | CA |
| Society for Cardiovascular Angiography and Interventions Association PAC | Q | DC |
| Society for Relief of Distressed and Decayed Pilots Political Action Committee | Q | DC |
| Society for the Preservation of the Arts | O | IL |
| Society for Vascular Surgery Political Action Committee | Q | IL |
| Society of American Florists Political Action Committee | Q | VA |
| Society of Chemical Manufacturers and Affiliates Political Action Committee (Socma Pac) | N | VA |