| Society of Independent Gasoline Marketers of America PAC | Q | VA |
| Society of Interventional Radiology Political Action Committee | Q | VA |
| Society of Thoracic Surgeons Political Action Committee | Q | DC |
| Sock and Awe PAC | O | MD |
| Soderberg 2018 Victory Fund | N | DC |
| Soderberg for Congress | H | FL |
| Sodexo INC. Political Action Committee | Q | MD |
| So It Has Come to This | N | IN |
| Solages for Congress | H | NY |
| Solano County Republican Central Committee (Fed. Acct.) | Y | CA |
| Solano United-Scdcc Federal Account | X | CA |
| Solar Energy Industries Association PAC (Solarpac) | Q | DC |
| Solaris League | N | MD |
| Soldati for Congress | H | NH |
| Soleo Health Holdings, INC. PAC | N | NH |
| Solers INC PAC | Q | VA |
| Sol Flores for Congress | H | IL |
| Solidarity Committee to Elect Brian Carroll | P | CA |
| Solidarity Political Action Committee | V | PA |
| Solidarity Victory PAC | O | PA |
| Solid Blue Strategies | O | CA |
| Solis for Congress | H | CA |
| Solis for Congress | H | CA |
| Solomon4congress | H | CA |
| Solomon for Congress | H | PA |
| Solomon for Congress 2024 | H | CA |
| Solomon Rajput for Congress | H | MI |
| Solorio for City Council 2022 | X | CA |
| Solorio for Congress | H | IL |
| Solstin Org | S | WA |
| Solution Fund PAC | O | LA |
| Solutions for Arizona | I | AZ |
| Solutions for Colorado | U | CO |
| Solutions Nj PAC | O | NJ |
| Solvay America, INC. Good Government Fund | Q | TX |
| Solv Energy LLC PAC | N | CA |
| Somali American Political Action Committee | N | OH |
| Some Astute Technology Operators Suggest Hodling Indefinitely | N | TX |
| Something Better Beginning | N | AZ |
| Somos Accion | I | — |
| Somos PAC | O | DC |
| Somos the Future | I | MN |
| Somos Votantes | E | DC |
| Somos Votantes | I | DC |
| Somos Votantes | O | DC |
| Sonia Rathburn for Congress | H | MS |
| Sonichu | P | VA |
| Sonja 4 Oregon | H | OR |
| Sonnenberg for Congress | H | CO |
| Sonoma County Democratic Party | Y | CA |
| Sonoma County Republican Central Committee (Federal) | Y | CA |
| Sons 2024 | H | OH |
| Sony Music Entertainment Employee Action Fund | Q | CA |
| Sony Pictures Entertainment, INC. PAC | Q | CA |
| Sooner Values PAC | O | WI |
| Soothe the Bern | N | DC |
| Sophia Alexander Campaign for Congress | H | CA |
| Soren Sorensen for US House | H | MN |
| Soriano for Congress | H | FL |
| Sos4america PAC | V | GA |
| Soules for US Congress | H | NM |
| Soulshine Reformers | P | OK |
| Soulutionator Eden'S Grassroots U.S.A. | P | DC |
| Sou Moua for Congress | H | CA |
| Soupyforcongress | H | MO |
| Souraya Faas Campaign | H | FL |
| Souraya Faas for President | P | FL |
| South Alabama Conservatives PAC | O | MD |
| South Asian American Forum (Saaf) | N | ZZ |
| South Asians Vote 2020 | U | NJ |
| South Asians Vote 2020 | I | NJ |
| South Bay Afl-Cio Labor Council | I | CA |
| South Carolina Conservative Leadership Fund | O | WI |
| South Carolina Equity Political Action Committee | N | SC |
| South Carolina Farm Bureau Federation Political Action Committee | N | SC |
| South Carolina God Party Israeli-American Platform | X | SC |
| South Carolina Libertarian Party Sclp | Y | SC |
| South Carolina Patriots PAC | O | MA |
| South Carolina Republican Party | Y | SC |
| South Carolina Trump Victory | N | MA |
| South Cord Management LLC | I | CA |
| South Dakota Association of Healthcare Organizations PAC | N | SD |
| South Dakota Bankers Association Public Affairs Committee (Sdbankpac) | Q | SD |
| South Dakota Democratic Party | Y | SD |
| South Dakota First | Q | SD |
| South Dakotan for Political Integrity | O | SD |
| South Dakota Republican Party | Y | SD |
| South Dakota State Medical Association Political Action Committee (Sdsmapac) | Q | SD |
| Southeast Asian Action | I | WI |
| Southeast Bluegrass PAC | O | WI |
| Southeast Cotton Committee (Secc) Southern Cottongrowers INC/Se Cotton Ginners Assn | Q | GA |
| South Eastern Conservatives PAC | N | TN |
| Southeastern Lumber Manufacturers Assoc Political Action Committee | Q | GA |
| Southeast Laborers District Council | C | TN |
| Southeast Milk INC Political Action Committee | Q | FL |
| Souther for Congress, INC. | H | GA |
| Southern Blue USA | O | TX |
| Southern Calif4nia Victory Fund | H | DC |
| Southern California District Council of Laborers | I | CA |
| Southern California Fund | Q | CA |
| Southern California Pipe Trades District Council 16 Federal PAC | Q | CA |
| Southern California Stewardship | O | CA |
| Southern Company Employees PAC | Q | GA |
| Southern Company Gas PAC, INC. | Q | GA |
| Southern Crop Production Assn Federal Political Action Committee | N | NC |
| Southern Equality Alliance | O | SC |
| Southern Futures A Political Action Committee | N | AL |
| Southern Glazer'S Wine and Spirits PAC | Q | FL |
| Southern Illinois Working Families PAC | O | MA |
| Southern Indiana Freedom PAC | O | GA |
| Southern Minnesota Beet Sugar Cooperative Political Action Committee | Q | MN |
| Southern National Congress | N | TN |
| Southern Nuclear Operating Company, INC. PAC | Q | AL |
| Southern Ohio Conservatives PAC | O | OH |
| Southern Progress | O | AR |
| Southern Progressives for J Bohren | S | MS |
| Southern Progress Victory Fund | S | DC |
| Southern Republican Cooperative | V | VA |
| Southern Resident Protection | N | WA |
| Southern Roots PAC | U | PA |
| Southern States Conservative Fund | V | AL |
| Southern States PAC | N | MS |
| Southern States Police Benevolent Assoc PAC Fund | Q | GA |
| South Florida Residents First | O | FL |
| South Georgia Victory Committee | N | TX |
| South Jersey First | N | MA |
| South Jersey Matters | O | NJ |
| South Jersey PAC | N | NJ |
| South Jersey Republican Coalition | N | NJ |
| South Jersey United in Trust (Sjuit) PAC | N | NJ |
| South Ms Concerned Citizens | O | MS |
| South Oc Taxpayers | O | WI |
| South Orange County Democratic Club | N | CA |
| South Pasadena Democratic Club | X | CA |
| Southpaw PAC | V | MI |
| South Shore Democratic Caucus Federal PAC | X | MA |
| South Shore Victory Fund | N | NY |
| South Sound Blue | U | WA |
| South Texans' Property Rights Association Fedpac | N | TX |
| South Texas Strong Leadership PAC | N | OH |
| South Texas Sugar Cane Producers PAC Rio Grande Valley Sugar Growers, INC | Q | TX |
| South Valley Water PAC | Q | CA |
| Southwest Airlines CO. Freedom Fund | Q | TX |
| Southwest Airlines Pilots' Association Political Action Committee (Swapa Pac) | Q | TX |
| Southwest Business Corporation PAC (Swbcpac) | Q | TX |
| Southwest Conservative PAC | V | MO |
| Southwestern Energy Company Political Action Committee | Q | TX |
| Southwest Gas Corporation Political Action Committee | Q | NV |
| Southwest Iowa Renewable Energy LLC PAC - Sire PAC | Q | IA |
| Southwest Leadership Fund | Q | DC |
| Southwest Ohio Leadership PAC | H | OH |
| Southwest Regional Council of Carpenters | C | CA |
| Southwest Regional Council of Carpenters Legislative Improvement Cmte United Brotherhood of Carpenters & Joiners of America | Q | CA |
| Southwest Virginia Rising | N | VA |
| Sovereignty National Committee | X | WI |
| Sowega PAC | N | GA |
| Sowell for Senate | S | TN |
| Space Coast Leadership PAC | N | FL |
| Space Exploration Technologies Corp. PAC | Q | DC |
| Spanberger for Congress | H | VA |
| Spanberger Victory Fund 2020 | N | DC |
| Spandau Campaign | H | TX |
| Spankthedonkeypac.Com | O | NH |
| Spanktheelephantpac.Com | O | ME |
| Spark PAC | N | DC |
| Spark Therapeutics, INC. PAC (Spark Pac) | Q | PA |
| Spaulding for Congress | H | IL |
| Speaker for Congress | H | NY |
| Speaker Trump Notary Public Officer Committee | O | NY |
| Speaker Trump Presidential Electors Notary Public Officers Committee | N | NY |
| Speak Free Or Die PAC | O | WI |
| Speak Up America Political Action Committee | Q | VA |
| Speak Up for Rural Electrification (Sure) | Q | KY |
| Speak Up PAC | V | DC |
| Speak Up Tn | V | TN |
| Spears for Congress | H | WA |
| Speciale for Congress | H | NC |
| Specialized Medicine and Responsible Treatment PAC | O | NY |
| Special Operations for America | O | NY |
| Special Operations Speaks PAC - Sos PAC | W | NC |
| Specialty Equipment Market Association PAC Semapac | Q | CA |
| Spectrum Healthcare Resources INC Political Action Committee (Shr Pac) | Q | MO |
| Speechnow.Org | O | DC |
| Speed PAC | Q | FL |
| Spelhouse Political Action Committee | N | NJ |
| Spencer for Senate Committee | S | NY |
| Spencer Morris for Congress 2022 | H | SC |
| Spencer Toder for Senate | S | MO |
| Spenser2020 | H | OR |
| S&P Global INC. Political Action Committee | Q | NY |
| Spike PAC | N | MA |
| Spike the Ball | N | CA |
| Spine PAC of the National Association of Spine Specialists | Q | IL |
| Spinney for Congress | H | CA |
| Spire INC. Federal Political Action Committee (Spire Federal Pac) | Q | MO |
| Spirit Aerosystems, INC. PAC | Q | KS |
| Spirit Airlines INC PAC Spirit PAC | N | FL |
| Spirit of 1776 | O | PA |
| Spirit of '76 PAC | Q | TX |
| Spirit of America PAC | Q | MA |